Prof. Peter Angel Signal Transduction and Growth Control

Cancer arises when cells are exposed to influences that damage the hereditary material. Radiation and certain chemical substances are examples of factors that can cause or promote cancer. In our working group we are trying to elucidate how such signals acting on a cell from the outside influence gene activity in the cell. Our special interest is devoted to a protein called AP-1 (Fos/Jun), a transcription factor that regulates the activity of subordinated genes. Using animal models, in vitro organ systems, and genome-wide expression analyses, we are studying which target genes are controlled by AP-1 and how AP-1 itself is regulated. We have been able to show that AP-1 is involved in numerous biological processes including the proliferation and death of cells and their transformation into tumor cells. Our aim is to elucidate the function of genes, to identify new diagnostic characteristics of cancer cells, and to develop novel therapies in collaboration with clinicians

Detailed information on the project can be found at
www.dkfz.de/en/signal_transduction/index.html