Prof. Elmar Schiebel Chromosome segregation in mitosis

Mitosis is the process by which a cell separates the duplicated genetic material, in order to generate two identical daughter cells. The overall aim of our research is to understand molecular mechanisms of mitosis. We use the budding yeast Saccharomyces cerevisiae and mammalian tissue culture cells as model systems. The laboratory has four key aspects of activity: (i) The mitotic exit network (MEN), (ii) a MEN-like network in vertebrate cells, (iii) components of the mitotic spindle, and (iv) the analysis of a novel control mechanism that becomes essential when the yeast centrosome is not correctly embedded into the nuclear envelope. Questions are addressed using a broad range of methods including yeast genetics, biochemistry, electron microscopy, live cell imaging, FRET, and molecular biology.

Detailed information on the project can be found at
www.zmbh.uni-heidelberg.de/Schiebel/default.shtml