PD Dr. Ursula Klingmüller Systems Biology of Signal Transduction

Our research objective is to decipher molecular mechanisms that regulate dynamic interactions in intracellular signaling networks and thereby control cellular decisions. When these control mechanisms fail cancer and other diseases arise. Signal transduction in intracellular networks comprises the transmission of information from cell surface receptors to the nucleus where the activity of genes is regulated. To elucidate key regulatory mechanisms it is not sufficient to identify the network components but rather essential to understand the dynamic behavior. In close collaboration with modeling partners we are following a systems biology approach and combine quantitative data with mathematical models to investigate alterations in signaling networks that promote the onset of cancer. The data-based mathematical models enable rapid testing of hypotheses, the targeted design of experiments and the prediction of steps most suitable for intervention. Thereby our approach can contribute to a more rapid development of effective anti-cancer therapies.

Detailed information on the project can be found at
www.dkfz.de/en/systembiologie/index.php